- Title
- Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
- Creator
- Gu, X.; Niu, J.; Dorahy, D. J.; Scott, R. D.; Agrez, M. V.
- Relation
- British Journal of Cancer Vol. 87, Issue 3, p. 348-351
- Publisher Link
- http://dx.doi.org/10.1038/sj.bjc.6600480
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2002
- Description
- There is general consensus that matrix metalloproteinases are involved in tumour progression. We show herein that inhibition of integrin αvβ6 expression in colon cancer cells suppresses MMP-9 secretion. This integrin-mediated event is dependent upon direct binding between the β6 integrin subunit and extracellular signal-regulated kinase 2. Targeting either β6 or its interaction with extracellular signal-regulated kinase in order to inhibit matrix metalloproteinase activity may offer a useful therapeutic approach in preventing growth and spread of colon cancer.
- Subject
- cellular signal transduction; metalloproteinases; protein kinases; colon cancer
- Identifier
- uon:1508
- Identifier
- http://hdl.handle.net/1959.13/27253
- Identifier
- ISSN:0007-0920
- Reviewed
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